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How long do you typically advise taking supplements such as GastroMend and GI Revive for?

Chris Kresser: Again, yeah, short-term use usually 30, 60 days is enough to address the symptoms and what’s going on,...

In the melatonin discussion, you stated that 6-OH melatonin sulfates are a good representation of the night’s production of melatonin but it can’t be used to monitor therapy. So keep that in mind when you’re interpreting results for melatonin. Is this because supplementing with melatonin will give very high results in the report, as you mentioned? It could still improve quality subjectively and other markers on DUTCH, right?

Chris Kresser: Yes, so it just means that the amount of 6-OH melatonin that’s excreted in the urine is very...

Do you have a list of commonly used supplements like a wish list created in Emerson and our natural partners that we ADAPT students can use for own practice? This would be very helpful. How do you organize and find supplements you frequently use in your practice? Does your office assistant keep some inventory of MegaSpore, Prescript Assist and other products that aren’t found in Emerson or natural partners?

Chris Kresser: Yeah, so Shelpie we actually are going to be launching a supplement store for Kresser Institute trained practitioners...

I’ve seen many supplements with deglycerinated licorice, such as RepairVite from Apex. What’s the benefit of this ingredient?

Dr. Amy Nett: It’s generally to soothe the stomach and help repair the mucosa, so it’s different than the...

I noticed that Iberogast has licorice root in it. Any idea of what the dose is? It’s only part of a proprietary blend. Is this taken into consideration when given to HPA patients?

Dr. Amy Nett: No, I don’t know what the dose is because, as you mentioned, it’s proprietary, but I think...

Vital Adapt was recommended, and I’m confused why that would be used because in the teaching Chris said that it was used in cases of low free cortisol, but hers is on the high end of normal.

Dr. Amy Nett: Yeah, that’s fair. I think this is one of those things where clinical judgment probably came into...

How long do you typically put patients on the supplement plan for HPA dysregulation, and when do you typically retest?

Dr. Amy Nett: This depends a lot, I think, on the severity of the symptoms and what the underlying issue...

When we learned the HPA supplement protocols, there wasn’t a focus on duration of treatment. So when to stop the supplements in the near long term. I feel like this is kind of a black hole for me.

Dr. Amy Nett: Yeah, exactly. There is more to the question, so I’m going to come back to it. It’s...

Also, because the choices are so supplement heavy in the case studies, I’m wondering how supplement heavy most of the cases are really and how you make choices. Are there any go-tos in the different categories that are your favorites? Do you start people with one thing at a time so you can monitor what each one is doing and how it is tolerated? Many of them don’t feel as ancestral based such as in the gut treatment section, meaning they seem more like extracts of things that you don’t find in nature. This is confusing to me because the protocols don’t seem as in alignment with the ancestral medicine approach except for things such as adaptogens.

Dr. Amy Nett: That’s a great point, but the other thing is, if you’re looking at an ancestral perspective, if...

So, what are your thoughts on this in terms of supplements not being ancestral?

Dr. Amy Nett: Agreed. I think if you can get your patients—and I think we have a couple people in...

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