In the melatonin discussion, you stated that 6-OH melatonin sulfates are a good representation of the night’s production of melatonin but it can’t be used to monitor therapy. So keep that in mind when you’re interpreting results for melatonin. Is this because supplementing with melatonin will give very high results in the report, as you mentioned? It could still improve quality subjectively and other markers on DUTCH, right?

Chris Kresser:  Yes, so it just means that the amount of 6-OH melatonin that’s excreted in the urine is very high and so it’s not sufficient as a means of monitoring endogenous melatonin production because as long as the patient’s taking melatonin, the 6-OH will be very high. So you can’t really tell if anything is changing related to their endogenous production. You wouldn’t necessarily expect that with melatonin supplementation, in fact you really wouldn’t. But it still sums up, some patients still do very well with melatonin supplementation and you just kind of ignore that marker on DUTCH if they’re taking it.