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When labs indicate intestinal permeability and microbial infection, what’s your approach to clearing or repairing, assuming you measure these with Cyrex 2 and 12, respectively?

Chris Kresser: Question that was sent in, I think, from Sandy, “When labs indicate intestinal permeability and microbial infection, what’s your approach to clearing or repairing, assuming you measure these with Cyrex 2 and 12, respectively?”

I totally understand why you all are asking me questions, and I would love to be able to answer them in a succinct way that makes sense. But given that we spend weeks on each of these subject areas in the curriculum, unfortunately, at least at first, I’m going to have to keep referring you to that material and just ask you to please be patient because we’re going to cover all of this in great depth. What I can say from a 30,000-foot view is that I don’t think that it’s useful or even productive to treat intestinal permeability until you have addressed the underlying issues that lead to permeability, which are infections like H. pylori [​Helicobacter pylori]​ or any other pathogens, parasites, fungal overgrowth, disrupted gut microbiome, [or] SIBO. All of those things are going to cause intestinal permeability. I think that’s the best way to approach it, and then we’ll talk about testing for permeability. There’s no one great test. The combination of lactulose, mannitol, and then the Cyrex Array 2 is a good way. And then for gut infections, no, I don’t use Cyrex. That’s just antibody production. I don’t think that really tells you what’s occurring in the gut. The Doctor’s Data, new full GI panel, we’re going to be covering the comprehensive stool analysis. Also, the Diagnostic Solutions GI-MAP is another good option.

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