Maybe I’m jumping ahead of myself here, as this will probably be covered in more detail in the blood chemistry portion, but how do you determine who’s a hyper-responder—familial hypercholesterolemia or ApoE4 genotype—to dietary cholesterol and saturated fat?

Chris Kresser:  Basically, as I said earlier, if you address all of the other underlying issues and the patient still has a high LDL particle number, it’s almost certain that they have some kind of genetic issue that is causing them to be a hyper-responder. And then if you put them on a lower-fat, higher-carb diet, like a Mediterranean Paleo type of diet, and their LDL-P and cholesterol go down, you can confirm that pretty easily. That’s how you do it.