Chris Kresser: Well, the dosage that has been used in most studies is 4.5 milligrams, but almost every clinician that I know that works with LDN starts patients on a lower dose of maybe 1 to 1.5 milligrams. They stick with that for three to five days, maybe seven days if they’re having trouble, then go up to 3 milligrams, stick with that seven days, or longer if they’re having trouble adjusting, if they have insomnia or side effects like that, and then go all the way up to the 4.5 milligram dose. In my experience, I would say the majority of people end up settling at around 3 milligrams. We do see patients that end up using the full 4.5 milligram dose, but I would say 60 or 70 percent, if not more, end up on a lower dose, somewhere between 2 and 3 milligrams, so it really depends on the patient.
- Home
- Knowledge Base
- Autoimmune Disorders
- How do you determine the dosage for LDN?
How do you determine the dosage for LDN?
Related Articles
- Do we know, in cases of molecular mimicry, [if] it is [a] coincidence that the pathogen is similar in structure to [the] host protein, or has the pathogen evolved to mimic proteins in an attempt to limit or prevent an immune response from the host?
- What are your thoughts on being prescribed DMARDs for rheumatoid arthritis when the Paleo template is working with decreased inflammation? Is there an alternative to baking soda? The plan was told by a rheumatologist. He didn’t know why diet was working for her; [it] may be coincidental.
- Hashimoto’s and neuropathy
- I have Raynaud’s in my fingers and occasional pernio in one of my toes. My 5-year-old has mild eczema and glaucoma, which could be autoimmune in her left eye, so I experimented with egg, dairy, and nightshade elimination to begin. There is no change in the 9-year-old’s psoriasis, so we did a 90-day AIP trial. The older daughter’s psoriasis improved a teeny bit, and I am wondering what test would be most beneficial and easy/practical bearing her age in mind to get to her root cause. I would love to do a stool test, but she is pretty disgusted by the idea of collecting the sample. It’s so much easier to figure this out for clients, but when my children are concerned, I cannot see the woods for the trees. I would really appreciate your thoughts.
- What’s your take on sudden onset of chilblains, first in the toes of one foot one day and then the toes of the other the next, after spending an hour in the cold, and this is in an eight-year-old who has mild psoriasis on the elbows but otherwise “healthy”?
- What do you make of the idea that there might be an autoimmune component in the pathogenesis of glaucoma?