Chris Kresser: I think what happens with IAP is disruption of the gut microbiome, which, of course, could be a cause of IP in the first place, so that might be a deeper cause and can be a result as well, and then you get inflammation. You get an overproduction of inflammatory cytokines, and that inflammation can affect all of the tissues in the digestive tract including the stomach, and that could lead to changes in the stomach that predispose to ulcer formation. Of course, the inflammation isn’t just limited to the gut it. The cytokines get into the bloodstream, and they can then go and affect other tissues elsewhere. I’m not sure of the exact mechanism off the top of my head, but that’s what I would suspect.
- Home
- Knowledge Base
- Autoimmune Disorders
- When discussing intestinal permeability, you showed a slide that listed a number of conditions associated with IP such as IBD, celiac, and other autoimmune diseases. I’m familiar with mechanisms connecting IP and these other conditions, and the connection makes a lot of sense. However, you also listed gastric ulcers as a symptom of intestinal permeability, and the mechanism behind that wasn’t clear to me. Can you explain how gastric ulcers could be a symptom of IP?
- Home
- Knowledge Base
- Gut Health
- When discussing intestinal permeability, you showed a slide that listed a number of conditions associated with IP such as IBD, celiac, and other autoimmune diseases. I’m familiar with mechanisms connecting IP and these other conditions, and the connection makes a lot of sense. However, you also listed gastric ulcers as a symptom of intestinal permeability, and the mechanism behind that wasn’t clear to me. Can you explain how gastric ulcers could be a symptom of IP?
When discussing intestinal permeability, you showed a slide that listed a number of conditions associated with IP such as IBD, celiac, and other autoimmune diseases. I’m familiar with mechanisms connecting IP and these other conditions, and the connection makes a lot of sense. However, you also listed gastric ulcers as a symptom of intestinal permeability, and the mechanism behind that wasn’t clear to me. Can you explain how gastric ulcers could be a symptom of IP?
Related Articles
- When labs indicate intestinal permeability and microbial infection, what’s your approach to clearing and repairing? I assume you measure these with Cyrex 2 and 12, respectively.
- With the increased consumption of kombucha, do we tell patients to avoid, if they have sensitivity to yeast, Saccharomyces cerevisiae, or is the SCOBY a different yeast not to be concerned about?
- Even if a patient is a wheat consumer, would you test for intestinal permeability prior to running the Cyrex 3 panel?
- Is a healthy and stable gut microbiome difficult and possible to risk among the following types of patients: (1) people in the study that I mentioned in which three or more generations on a low-fiber diet led to permanent loss of key microbes; (2) individuals that have never been colonized normally, like people who were born [via] a C-section or [were] formula-fed; (3) individuals whose mucosal microbiome and immune system vigilantly exclude newcomers resulting in unsuccessful causation [2:47] of probiotics.
- I see the course content was updated to reflect Seed replacing Prescript-Assist. Does TerraFlora then replace MegaSpore Biotic? (generally)
- When labs indicate intestinal permeability and microbial infection, what’s your approach to clearing or repairing, assuming you measure these with Cyrex 2 and 12, respectively?