For most cases, with our ADAPT Level One knowledge, would you recommend treating the exposome and gut first before DUTCH testing for prioritizing?

Chris Kresser:  That’s a good question. I think it really depends on the patient, and this is where an intake is so important. Let’s consider a couple different patients. So, one is a type A personality. He is not doing any stress management. He is working 60- to 70-hour weeks. He has no awareness about light exposure. He is using computers or tablets right up until bedtime. He travels a lot across time zones. He is taking care of his ailing mother, who has Alzheimer’s disease. You get the idea, right? He has blood sugar dysregulation and inflammation. He has every HPA axis disruptor in the book. In that case, my focus is going to be on the HPA axis probably first of all because I think no matter what you do with the gut, the HPA axis is really going to sabotage your efforts. Now addressing the gut, if it is a source of inflammation, which is affecting the HPA axis, it might be part of that protocol, but you really have to focus on what you feel like the primary driver is for the patient, and that will vary from patient to patient. It’s hard to answer that with a formula that will work for every patient.